The neurotrophic and morphogenic activities of gdnf are mediated by its interaction with a multicomponent receptor complex formed by the ret receptor tyrosine kinase and a glycosylphosphatidylinositol ( gpi ) - anchored " accessory " receptor , gdnf family receptor alpha - 1 ( gfral ) Gdnf的神經(jīng)營養(yǎng)作用主要是通過兩類受體亞基介導,即膠質細胞源性神經(jīng)營養(yǎng)因子受體alpha ( gfr s )亞基和受體酪氨酸激酶ret亞基。